Some (Statistical) Threats and Possible Solutions to Accurately Estimate Ongoing Transmission in the Current Agenda of Malaria Elimination

Sala 6.4.31, FCUL, Lisboa

Por Nuno Sepúlveda (London School of Hygiene and Tropical Medicine & CEAUL).

Malaria elimination is currently on the agenda of more than 30 countries worldwide. This agenda brings unprecedented epidemiological challenges on how to accurately measure ongoing transmission. On the one hand, epidemiological measures based on the detection of infection might be uninformative due to the high probability of not sampling any infected individual in surveillance studies. Moreover, countries like Ethiopia, Eritrea or Peru are currently facing problems of detecting an increasing number of malaria cases infected with Plasmodium falciparum parasites lacking the histidine-rich protein-2 (pfHRP2) gene, whose protein product is on the basis of most popular rapid diagnostic tests. On the other hand, sero-epidemiological studies based on antibody data are gaining popularity among the scientific community, because they aim to estimate parasite exposure rather than infection. However, current statistical methods for the corresponding data analysis shows some limitations due to the use of (i) biased estimators for estimating key sero-epidemiological parameters, (ii) of simplified model assumptions for the data, and (iii) of study designs with reduced epidemiological power. This talk will present a global meta-analysis of the available data about the prevalence of pfHRP2 deletions and the respective association with other relevant genes for malaria diagnostics. It will also discuss some simple solutions for increasing the statistical reliability of future sero-epidemiological studies.  

CEAUL - Centro de Estatística e Aplicações da Universidade de Lisboa
SPOF 2018 Summer School on “Topics in Optics for Space & Ground Based Astronomical Instruments”

The SPOF 2018 Summer School on “Topics in Optics for Space & Ground Based Astronomical Instruments” will happen in 10 and 11 of September 2018 at the Physics Department of the Faculdade de Ciências da Universidade de Lisboa.

Orçamento Participativo Portugal

O Orçamento Participativo Portugal é um processo democrático deliberativo, direto e universal, através do qual as pessoas apresentam propostas de investimento e que escolhem, através do voto, quais os projetos q

SPINON Workshop 2018

A platform that brings together renowned scientists and young researchers in the field of molecular magnetism.

EuCheMSIL 2018 - 27th Conference on Molten Salts and Ionic Liquids

This series of meetings initiated in 1966 as EUCHEM Conference on Molten Salts in Norway. After molten salt and ionic liquid communities joined forces in 2006, it developed to a true European event organized every two years.

O Encontro Nacional de Biologia Evolutiva tem como objetivo principal juntar Biólogos Evolutivos a trabalhar em Portugal e no estrangeiro, de modo a promover coesão e excelência científica.

Cursos Avançados cE3c 2018/2019

The course “Entomological Collections, Insect Systematics and Evolution” will comprehend a general introduction to entomology and entomological collections, covering the steps various steps for the creation of such a collection: specimen capture and preparation, cataloguing, di

Cursos Avançados cE3c 2018/2019

O programa detalhado de Cursos Avançados disponibilizados pelo cE3c - Centro de Ecologia, Evolução e Alterações Ambientais para o ano letivo 2018/2019 já está disponível.

Cursos Avançados cE3c 2018/2019

There are thousands of totally sequenced genomes freely available in the Internet. The number keeps on growing as at least one genome sequence is released every day.

Natural History Collections and Biodiversity

Natural history museums are privileged spaces for seminal research on different subjects of biological sciences such as biodiversity, evolution, ecology, biogeography and taxonomy.

Cursos Avançados cE3c 2018/2019

Objectives: To introduce participants to the details of communicating science to non-specialized audiences, including, but not exclusive to, public and private stakeholders, students and teachers, and media professionals.

EIT Health

The European Institute of Innovation & Technology (EIT) Health promotes healthy living, active ageing and improvements in healthcare.

Marte 2030 - Ciclo de conversas com os pés assentes em Marte

Por Rui Agostinho (IA/Faculdade de Ciências da Universidade de Lisboa) e Pedro Fevereiro (ITQB-NOVA).

Congresso "Ciência, Cultura e Turismo Sustentável"

Inserido nas celebrações do Ano Internacional do Turismo Sustentável 2017 e do Ano Europeu do Património Cultural 2018, o congresso pretende lançar olhares cruzados sobre os temas da Ciência, Cultura e Turismo Sus

Marte 2030 - Ciclo de conversas com os pés assentes em Marte

Por Pedro Machado (IA/Faculdade de Ciências da Universidade de Lisboa) e Isabel Abreu (ITQB-NOVA).

Cursos Avançados cE3c 2018/2019

The objective of this course is to introduce participants to the details of communication and writing scientific publications. The main emphasis is on the most common form, the “primary scientific paper”, but other forms will be covered.

Cursos Avançados cE3c 2018/2019

Under the general framework of Global Change Ecology, the goal of this course is to provide the participants with the most recent and practical knowledge on the use of Functional Diversity.

Cursos Avançados cE3c 2018/2019

This course introduces the field of island biogeography, a discipline that has long influenced other research areas such as macroecology, community ecology, evolution and conservation biology.

Cursos Avançados cE3c 2018/2019

Lack of fertile land to feed the exponentially growing population, insufficient water availability and quality, changes in the flow of nutrients through the bio-geo-cycles (especially N and P) and climate and land use changes are impacting ecosystems and their capacity to deliv

Cursos Avançados cE3c 2018/2019

Symbiosis is a key strategy for life on Earth. Nevertheless, although many research groups have long been committed to the study of symbiosis, its definition and functioning are not fully understood, and its ecological role and relevance are still underestimated.

Cursos Avançados cE3c 2018/2019

Phylogenetics is one of the scientific areas of Biology that has grown fast and evolved in methodological terms in the last years.

In preparation for the new decade, society urgently needs to implement actions that can make us more resilient to the challenges of the 21st century.

Plastics Heritage Congress

Under the aegis of the Plastics Heritage European Association (PHEA), the Portuguese Center for the History of Science and Technology (CIUHCT) will host the Plastics Heritage Congress 2019.