Encontros Scientia

Dissecting out disease mechanisms using developmental biology: The case of LAMA2- deficient muscular dystrophy

Sala 2.2.14, FCUL, Lisboa

Por Solveig Thorsteinsdóttir (Development and Evolutionary Morphogenesis - cE3c).

Skeletal muscle development starts early in vertebrate embryos and progressively builds the skeletal muscles that make us able to move and breathe. Throughout most of our lives, skeletal muscle is a tissue with remarkable regenerative potential because it contains muscle stem cells, derived from embryonic muscle progenitor cells, which are tucked into a specific “niche” near the muscle fibres. When we grow as children or when our muscles are damaged, some of these cells turn on the muscle developmental programme leading to muscle growth and/or repair.

Congenital muscular dystrophies (CMDs) are diseases where the connection between muscle cells and the extracellular matrix molecule laminin 211 is faulty, leading to muscle weakness evident already at birth. LAMA2-CMD, where laminin 211 is absent, is among the most severe CMDs. Muscle damage and wasting starts early in life and patients rarely survive past their teens or early twenties. There is no treatment or cure.

Since infants with LAMA2-CMD are already affected at birth, the defect underlying the disease must have arisen during development in utero. Using a mouse model for the disease we have discovered that Lama2-deficient mouse foetuses display impaired muscle growth in utero and have abnormally low numbers of muscle stem cells within their muscles. The timing of this defect correlates with the stage where, during normal muscle development, the muscle stem cells enter their niche, which in the case of mutant foetuses, lacks laminin 211. To dissect out what causes this reduction, we are zooming in on how muscle stem cells normally interact with their niche and what goes wrong in the absence of laminin 211. Our objective is to identify molecules or pathways that can be targeted in early intervention therapies which may one day increase the lifespan, improve clinical outcomes and quality of life for LAMA2-CMD patients.

12h00-13h00
cE3c - Centro de Ecologia, Evolução e Alterações Ambientais

Seminário de Lógica Matemática, por Luis Pereira (Universidade de Lisboa).

Cartaz da iniciativa

Sessão de esclarecimento sobre o Laboratório de Cidadãos “Peças de Jardim”.

Fotografia da oradora e identificação do evento

Talk @LASIGE, com Diana Costa (LASIGE).

Seminário do Departamento de Física de Ciências ULisboa, por Miguel Zilhão (CENTRA - Center for Astrophysics and Gravitation, Instituto Superior Técnico).

BioISI Research Seminar, por Sophie Jackson (University of Cambridge, UK).

Imagem ilustrativa do evento (saúde e medicina)

A participação nos eventos é gratuita, mediante inscrição prévia.

Logótipo dos 100 anos da criação da licenciatura em Engenharia Geográfica/Geoespacial

A participação no evento é gratuita, mediante inscrição obrigatória até 12 de outubro de 2021.

Logótipo do consórcio e imagem de pessoa a usar máscara

2.ª Conferência Anual Lisbon Living + tem como objetivo reunir a academia, a saúde, a sociedade e os setores de inovação e tecnologia para analisar os impactos da pandemia COVID-19 em Portugal e recolher lições para o futuro.

Conversa com Galopim de Carvalho.

The objective of this course is to introduce participants to the details of communication and writing scientific publications.

Seminário Permanente de Filosofia das Ciências, por Anna Ciaunica (CFCUL/GI2).

Research at the Faculty of Sciences

Save the date: 27 October 2021!

Seminário conjunto do Centro de Estatística e Aplicações da Universidade de Lisboa e do Centro de Matemática Computacional e Estocástica, por Kristen Campbell (University of Colorado Anschutz Medical Campus, USA).

Geometry Webinar, por Giosuè Muratore (CMAFcIO).

Conversa com Galopim de Carvalho.

Logótipo da IAESTE, sobre uma fotografia da cidade de Edimburgo

Candidaturas online de 01 a 31 de outubro 2021.

Imagem alusiva ao Concerto e Conferência

Concerto e conferência pela Orquestra Metropolitana de Lisboa.

Imagem ilustrativa do programa, acompanhada do respetivo título

Um programa de aceleração de ideias e negócios, promovido pela redeSaúde, com candidaturas até 15 de outubro de 2021.

Conversa com Galopim de Carvalho.

The objective of this course is to introduce participants to the details of communicating science to non-specialized audiences, including, but not exclusive to, public and private stakeholders, students and teachers, and media professionals.

Conversa com Galopim de Carvalho.

The course aims at providing an introduction to stable isotopes ratios as tools to understand global, ecosystem and community level bio/geo cycles; light isotopes: H, N, C, O and S isotopes, geo cycles and ecological significance; sampling and analytical methodologies in stable isotope analysis.

This course aims to evidence the importance of natural history collections for the study of biodiversity, to show new tools and approaches to extract and disseminate biodiversity data from natural history collections and to increase awareness of young researchers for the scientific and cultural value of Natural History Museums.

Conversa com Galopim de Carvalho.

EvoS aims at turning evolutionary theory into a common language to areas that pertain to the natural world, including human affairs.

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