Encontros Scientia

Dissecting out disease mechanisms using developmental biology: The case of LAMA2- deficient muscular dystrophy

Sala 2.2.14, FCUL, Lisboa

Por Solveig Thorsteinsdóttir (Development and Evolutionary Morphogenesis - cE3c).

Skeletal muscle development starts early in vertebrate embryos and progressively builds the skeletal muscles that make us able to move and breathe. Throughout most of our lives, skeletal muscle is a tissue with remarkable regenerative potential because it contains muscle stem cells, derived from embryonic muscle progenitor cells, which are tucked into a specific “niche” near the muscle fibres. When we grow as children or when our muscles are damaged, some of these cells turn on the muscle developmental programme leading to muscle growth and/or repair.

Congenital muscular dystrophies (CMDs) are diseases where the connection between muscle cells and the extracellular matrix molecule laminin 211 is faulty, leading to muscle weakness evident already at birth. LAMA2-CMD, where laminin 211 is absent, is among the most severe CMDs. Muscle damage and wasting starts early in life and patients rarely survive past their teens or early twenties. There is no treatment or cure.

Since infants with LAMA2-CMD are already affected at birth, the defect underlying the disease must have arisen during development in utero. Using a mouse model for the disease we have discovered that Lama2-deficient mouse foetuses display impaired muscle growth in utero and have abnormally low numbers of muscle stem cells within their muscles. The timing of this defect correlates with the stage where, during normal muscle development, the muscle stem cells enter their niche, which in the case of mutant foetuses, lacks laminin 211. To dissect out what causes this reduction, we are zooming in on how muscle stem cells normally interact with their niche and what goes wrong in the absence of laminin 211. Our objective is to identify molecules or pathways that can be targeted in early intervention therapies which may one day increase the lifespan, improve clinical outcomes and quality of life for LAMA2-CMD patients.

cE3c - Centro de Ecologia, Evolução e Alterações Ambientais

Speaker: Andrei Sipos (TU Darmstadt & Institute of Mathematics of the Romanian Academy).

Face à emergência da pandemia da COVID-19, a 6.ª edição da Escola de Verão de Energia da Faculdade de Ciências da ULisboa, prevista para 6 a 10 de julho de 2020, será adiada para data a definir em 2021.

CoastNet - Rede Portuguesa de Monitorização Costeira é uma infraestrutura de investigação MARE, que faz parte do Roteiro Nacional de Infraestruturas de Investigação de Interesse Estratégico (RNIE-FCT). Através do seu funcionamento est

Speaker: Elvira Zappale (Università Degli Studi di Salerno).

Cancelamento motivado pela aplicação do plano de contingência da Faculdade de Ciências da Universidade de Lisboa, na sequência das orientações da Direção-Geral de Saúde e das recomendações por parte da Reitoria da Universidade de Lisboa, relativamente ao novo Coronavírus (CO

Apresentações de Andreia Figueiredo (Ciências ULisboa) e Paula Silva (ICBAS.UPorto / Science & Wine).

Candidaturas a decorrer até ao dia 15 de julho de 2020.

IN3+  | Um Milhão para a Inovação.

O prémio IN3+ destina-se a todos os investigadores pertencentes às entidades que integram a Rede Inovação INCM.

Cancelamento motivado pela aplicação do plano de contingência da Faculdade de Ciências da Universidade de Lisboa, na sequência das orientações da Direção-Geral de Saúde e das recomendações por parte da Reitoria da Universidade de Lisboa, relativamente ao novo Coronavírus (COVID-1

Speaker: Gonçalo Tabuada (FCTUNL).

New date: September 14th-16th, 2020.

Ciências ULisboa associa-se ao maior evento mundial sobre inovação para a sustentabilidade - “The Planetiers World Gathering” - que terá lugar no Altice Arena entre 21 e 23 de outubro de 2020, sob os auspícios da

Programa de Formação Contínua de Professores do Ensino Básico (3.º ciclo) e Secundário, grupos 420 e 520.

Leitura e escrita são a base fundacional de todas as literacias e a condição primeira para o juízo compreensivo e crítico, o enriquecimento cultural, a formação estética e a memória individual e coletiva das sociedades.

Overview: Currently, climate changes or alterations are known to be reflected on the stable isotope ratios of Hydrogen, Nitrogen, Carbon, Oxygen and Sulphur present in atmospheric gas forms, fresh or ocean water, as well as in plants and animals and organi

Objectives: Evolutionary theory provides a framework for understanding all living systems.

Objectives: To introduce participants to the details of communicating science to non-specialized audiences, including, but not exclusive to, public and private stakeholders, students and teachers, and media professionals.

Objectives: Natural history museums are privileged spaces for seminal research on different subjects of biological sciences such as biodiversity, evolution, ecology, biogeography and taxonomy.

Objectives: Provide students with basic workflows, platforms and tools to increase reproducibility at all scientific levels.

Objectives: Under the general framework of Global Change Ecology, the goal of this course is to provide the participants with the most recent and practical knowledge on the use of Functional Diversity.

Objectives: The objective of this course is to introduce participants to the details of communication and writing scientific publications. The main emphasis is on the most common form, the “primary scientific paper”, but other forms will be covered.

Objectives: Lack of fertile land to feed the exponentially growing population, insufficient water availability and quality, changes in the flow of nutrients through the bio-geo-cycles (especially N and P) and climate and land use changes are impacting ecosystem

Objectives: Symbiosis is a key strategy for life on Earth.

Objectives: The goal of this course is to provide to the participants with current and practical knowledge on urban ecology, including ecological and social aspects. It aims at providing an integrated approach on urban socio-ecological systems.

Objectives: Citizen science can be part of the larger process of engaging people in new forms of interaction in scientific research, challenging scientists and citizens whilst enlarging scientific knowledge and providing learning opportunities for all part

New date: 30 August - 03 September 2021.

This conference is the 22nd in the series of triennial conferences which bring together the Particle and Nuclear Physics communities.