BioISI Research Seminar

From genome to cystic fibrosis: Single cell systems biology and drug targeting

Auditório da FCiências.ID, Lisboa

Por Hans V. Westerhoff (SysBA - Systems Biology Amsterdam / Synthetic Systems Biology and Nuclear Organization, University of Amsterdam / Molecular Cell Physiology, VU University Amsterdam / Em. Systems Biology, University of Manchester).

Abstract: Where Molecular Biology helped with biomolecules, Systems Biology enables us to deal with networks. Both disciplines were catapulted by the development of new techniques, such as cloning and whole genome sequencing. Together they have led to the realization that biological function as well as malfunction emerges from synergies in the molecular networks of cells and tissues. Therapies should better mind these synergies. In these approaches there was no accommodation yet of the phenomenon that tissues are themselves ‘societies’ of cells. Referring to novel technologies such as single cell mRNA sequencing and fluorescence in situ hybridization, I shall single-cell resolved systems biology. Transcription bursting, polysomal translation, and other batch wise processes can generate substantial diversity within a clonal cell population. Such ‘noise’ may not only provide a bet-hedging mechanism for drug resistance of tumors, but also ‘pace makers’ for developmental biology and immunology. Cell-cell variability may also be important for diseases such as cystic fibrosis: Within the same tissue some cells might be more affected than others, just like within the human population, some individuals are more affected by the same mutation, than others For the inquisitive it is now possible, through the Infrastructure for Systems Biology Europe (ISBE), to engage with systems biology. For cystic fibrosis we shall show how high quality input from an expert group in cystic fibrosis, had produced a model that by leads to counterintuitive discoveries. These include the elimination of apparently plausible drug targets, and the directing of the research to more plausible ones.

Host: Margarida Amaral (FunGP - BioISI).

11h30
BioISI - Instituto de Biossistemas e Ciências Integrativas

05 de junho: uma data especial para Ciências ULisboa, pois o ambiente está no centro das preocupações da comunidade da nossa Escola.

Speaker: Lucio Boccardo (Università di Roma La Sapienza).

To get access to the password, please register on the website or contact one of the organizers.

Objectives: provide students with statistical knowledge and tools to manipulate, analyze and visualize biological data with R. Introduction to modeling, simulations and Bayesian statistics.

Apresentações de João Cordovil (Centro de Filosofia das Ciências da Universidade de Lisboa / Ciências ULisboa) e Diana Barbosa (Comcept - Comunidade Céptica Portuguesa).

The Sustainable Energy Week, organised by the European Commission each year in June, will be organised as an online event this year on 23 to 25 June, under the theme "Beyond the crisis: clean energy for green recovery and growth".

Face à emergência da pandemia da COVID-19, a 6.ª edição da Escola de Verão de Energia da Faculdade de Ciências da ULisboa, prevista para 6 a 10 de julho de 2020, será adiada para data a definir em 2021.

Cancelamento motivado pela aplicação do plano de contingência da Faculdade de Ciências da Universidade de Lisboa, na sequência das orientações da Direção-Geral de Saúde e das recomendações por parte da Reitoria da Universidade de Lisboa, relativamente ao novo Coronavírus (CO

Candidaturas a decorrer até ao dia 15 de julho de 2020.

IN3+  | Um Milhão para a Inovação.

O prémio IN3+ destina-se a todos os investigadores pertencentes às entidades que integram a Rede Inovação INCM.

Cancelamento motivado pela aplicação do plano de contingência da Faculdade de Ciências da Universidade de Lisboa, na sequência das orientações da Direção-Geral de Saúde e das recomendações por parte da Reitoria da Universidade de Lisboa, relativamente ao novo Coronavírus (COVID-1

New date: September 14th-16th, 2020.

Ciências ULisboa associa-se ao maior evento mundial sobre inovação para a sustentabilidade - “The Planetiers World Gathering” - que terá lugar no Altice Arena entre 21 e 23 de outubro de 2020, sob os auspícios da

Programa de Formação Contínua de Professores do Ensino Básico (3.º ciclo) e Secundário, grupos 420 e 520.

Overview: Currently, climate changes or alterations are known to be reflected on the stable isotope ratios of Hydrogen, Nitrogen, Carbon, Oxygen and Sulphur present in atmospheric gas forms, fresh or ocean water, as well as in plants and animals and organi

New date: 30 August - 03 September 2021.

This conference is the 22nd in the series of triennial conferences which bring together the Particle and Nuclear Physics communities.