BioISI Research Seminar

From genome to cystic fibrosis: Single cell systems biology and drug targeting

Auditório da FCiências.ID, Lisboa

Por Hans V. Westerhoff (SysBA - Systems Biology Amsterdam / Synthetic Systems Biology and Nuclear Organization, University of Amsterdam / Molecular Cell Physiology, VU University Amsterdam / Em. Systems Biology, University of Manchester).

Abstract: Where Molecular Biology helped with biomolecules, Systems Biology enables us to deal with networks. Both disciplines were catapulted by the development of new techniques, such as cloning and whole genome sequencing. Together they have led to the realization that biological function as well as malfunction emerges from synergies in the molecular networks of cells and tissues. Therapies should better mind these synergies. In these approaches there was no accommodation yet of the phenomenon that tissues are themselves ‘societies’ of cells. Referring to novel technologies such as single cell mRNA sequencing and fluorescence in situ hybridization, I shall single-cell resolved systems biology. Transcription bursting, polysomal translation, and other batch wise processes can generate substantial diversity within a clonal cell population. Such ‘noise’ may not only provide a bet-hedging mechanism for drug resistance of tumors, but also ‘pace makers’ for developmental biology and immunology. Cell-cell variability may also be important for diseases such as cystic fibrosis: Within the same tissue some cells might be more affected than others, just like within the human population, some individuals are more affected by the same mutation, than others For the inquisitive it is now possible, through the Infrastructure for Systems Biology Europe (ISBE), to engage with systems biology. For cystic fibrosis we shall show how high quality input from an expert group in cystic fibrosis, had produced a model that by leads to counterintuitive discoveries. These include the elimination of apparently plausible drug targets, and the directing of the research to more plausible ones.

Host: Margarida Amaral (FunGP - BioISI).

11h30
BioISI - Instituto de Biossistemas e Ciências Integrativas

Conversa com Galopim de Carvalho.

The objective of this course is to introduce participants to the details of communication and writing scientific publications.

Seminário de Lógica Matemática, por Bruno Jacinto (Universidade de Lisboa).

Seminário de Formação Avançada em Jardins, Paisagens e Ambiente, por Daniela Araújo e Mauro Nascimento (Museu de Lisboa | EGEAC).

Seminário Permanente de Filosofia das Ciências, por Anna Ciaunica (CFCUL/GI2).

Research at the Faculty of Sciences

Participation is free but prior registration is suggested.

Seminário conjunto do Centro de Estatística e Aplicações da Universidade de Lisboa e do Centro de Matemática Computacional e Estocástica, por Kristen Campbell (University of Colorado Anschutz Medical Campus, USA).

Logótipo do evento, sobre um fundo branco

A iniciativa conta com o apoio do Centro Interuniversitário de História das Ciências e da Tecnologia.

Encontro Scientia, por Rui A. P. Perdigão (EChanges - Chair Professor and Head of the Met Institute for Complex System Science, Vienna, Austria / NORA Climate Dynamics and Complexity Chair, Vienna, Austria & Princeton NJ USA / CCIAM coordinator at cE3c, Lisboa, Portugal).

Hi-Phi Seminar, por Nathalie Gontier (Ciências ULisboa, CFCUL) e Luís Tirapicos (Ciências ULisboa, CIUCHT).

Geometry Webinar, por Giosuè Muratore (CMAFcIO).

Conversa com Galopim de Carvalho.

Logótipo da IAESTE, sobre uma fotografia da cidade de Edimburgo

Candidaturas online de 01 a 31 de outubro 2021.

Imagem alusiva ao Concerto e Conferência

Concerto e conferência pela Orquestra Metropolitana de Lisboa.

Encontro Scientia, por Maria Amélia Martins Loução (PSE - cE3c).

Imagem ilustrativa do programa, acompanhada do respetivo título

Um programa de aceleração de ideias e negócios, promovido pela redeSaúde, com candidaturas até 15 de outubro de 2021.

Conversa com Galopim de Carvalho.

The objective of this course is to introduce participants to the details of communicating science to non-specialized audiences, including, but not exclusive to, public and private stakeholders, students and teachers, and media professionals.

Conversa com Galopim de Carvalho.

The course aims at providing an introduction to stable isotopes ratios as tools to understand global, ecosystem and community level bio/geo cycles; light isotopes: H, N, C, O and S isotopes, geo cycles and ecological significance; sampling and analytical methodologies in stable isotope analysis.

This course aims to evidence the importance of natural history collections for the study of biodiversity, to show new tools and approaches to extract and disseminate biodiversity data from natural history collections and to increase awareness of young researchers for the scientific and cultural value of Natural History Museums.

Conversa com Galopim de Carvalho.

EvoS aims at turning evolutionary theory into a common language to areas that pertain to the natural world, including human affairs.

Conversa com Galopim de Carvalho.

Fotografia de plantas

Pre-proposals submission until 30 November 2021, 15:00 CET(local time in Brussels).

Páginas