BioISI Post Graduate Seminars

Auditório da FCiências.ID, Lisboa

Por Tânia Marques e Diana Pimentel (BioSYS PhD Program).

An integrative approach to tissue-specific effects of miRNA regulatory networks - Tânia Marques

MicroRNAs or miRNAs are small noncoding RNAs with a major role in post-transcriptional regulation of gene expression. miRNAs become part of the RISC complex which binds to miRNA responsive elements located predominantly in the 3’UTRs of target mRNAs through base-pairing interactions involving the miRNA seed sequence leading to degradation or translational inhibition of the mRNA molecule. Even though the basic mechanisms for miRNA action have been described, we are still unable to efficiently predict the impact of these molecules on cellular function. miR function has been proposed to be regulated by endogenous competing RNAs, including both coding and noncoding RNA molecules. This suggests that the ability of a given miRNA to act upon a target is dynamically influenced by the transcriptome environment it is in, in addition to the binding affinity it displays to different targets. Thus, when predicting targets for a miRNA, the context in which it is expressed needs to be accounted for. The aim of this work is to comprehensively understand the interaction dynamics between microRNAs and their target transcriptome across different conditions. This will be achieved by dissecting miRNA regulatory networks through correlation analysis between miRNA, mRNA and predicted targets in public datasets for different tissues and conditions.

Transcriptional and metabolic regulation of grape berry metabolism upon powdery mildew infection - Diana Pimentel

Grapevine (Vitis vinifera L.) is very susceptible to several diseases and one of the most problematic is powdery mildew (PM). PM is caused by the obligate biotrophic fungus Erysiphe necator and it affects grapevine yield and berry quality. In this study, naturally infected and control grapes from Carignan variety were collected at green (EL33) and véraison (EL35) stages and metabolic and transcriptomic changes upon PM infection of susceptible grapes were analyzed. Metabolic profiling of control and infected berries was performed by gas chromatography coupled to electron impact ionization/time-of-flight mass spectrometry (GC-EI/TOF-MS) and by solid phase microextraction (SPME) associated with GC-EI-MS. Thirty-six metabolites showed differential content comparing either infected and control samples or green and véraison stages. Among these, twenty were shown to be positive markers of infection including five metabolites that were undetected in control samples. RNAseq analysis was performed to access the expression profile of PM infected and control berries at both stages and 4275 genes were identified as differentially expressed due to infection and/or ripening, and they are mainly associated with response to biotic stress, secondary metabolism (phenylpropanoid and terpene pathways) and hormone metabolism, including salicylic acid and jasmonates. Altogether, these data suggest a metabolic and transcriptomic reprogramming upon infection with PM in particular at green stage.

BioISI - Instituto de Biossistemas e Ciências Integrativas
Logótipo da ULisboa, sobre um fundo escuro e ondas sonoras

Submissão de propostas até 06 de fevereiro de 2023.

Symbiosis is a key strategy for life on Earth. Nevertheless, although many research groups have long been committed to the study of symbiosis, its definition and functioning are not fully understood, and its ecological role and relevance are still underestimated.

Título do evento, inserido em composição de imagens alusivas ao cérebro e a puzzles

Um curso interdisciplinar dirigido a todos os que tenham interesse nas áreas de Neurociências e Filosofia.

Este Workshop tem como objetivos divulgar a política de criação de materiais didáticos de Ciências ULisboa, bem como saber identificar e utilizar as licenças Criative Commons.

Este Workshop tem como objetivo dar a conhecer os Recursos Educacionais Abertos e como tirar proveito desse recurso.

Título, resumo, data e horário do evento, acompanhados de logótipo das entidades organizadoras e de fotografia de plantas

Um workshop essencial para todos os que cuidam de plantas ornamentais.

This 5-day course offers to the participants a light microscopy course focusing on fluorescence microscopy techniques applied to the detection of proteins and glycans in tissue samples and cell cultures.

Titulo, dia, hora e local do evento, acompanhados de fotografias dos oradores

O que acontece quando os temas comentados nos media são controversos e os/as investigadores/as sofrem comentários negativos nos media ou online, ou mesmo ameaças? O que pode ou deve o investigador fazer? E como podem também apoiá-lo a sua instituição e os comunicadores que com ele/a trabalham?

Reflexo do pôr-do-sol nas águas do rio Tejo

Call for Proposals: Multi-Year Projects and Events.

Título, data, hora, local e logótipos das entidades promotoras do evento

In this panel discussion we will compare scientific research processes in Portugal and the US.

Fotografia da Praça do Comércio, em Lisboa

Candidaturas ao prémio (versões preliminares dos artigos) até 28 de fevereiro de 2023.

Título do evento, sobre uma fotografia do Large Hadron Collider

The objective of the course is to introduce the physics, analysis methods and results on the physics areas covered by the LHC experiments.

This course aims to explore ways of communicating science to non-specialized audiences, such as policy makers, industry, general public (including students and teachers), through their engagement and participation in citizen science activities.

Estudante a trabalhar em frente ao computador

A ULisboa irá atribuir 30 bolsas de doutoramento no âmbito da European University Unite!

A 19 de abril de 2023 celebra-se o 112.º aniversário da Faculdade de Ciências da Universidade de Lisboa.

Logótipo do evento, sobre um fundo branco

This year our motto is "Reinventing Science, for yourself and others”.

BioISI Research Seminar, por Margarida Gama-Carvalho (BioISI/Ciências ULisboa).

Título e data do evento, sobre uma fotografia de jovens cientistas

Faz a tua pré-inscrição e garante o teu lugar!

The objective of this course is to provide students with basic knowledge of R programming, allowing them to manipulate and visualize data with R.

The objective of this course is to provide students with statistical knowledge and tools to manipulate, analyze and visualize biological data with R. Introduction to modeling, simulations and Bayesian statistics.

Under the general framework of Global Change Ecology, the goal of this course is to provide the participants with the most recent and practical knowledge on the use of Functional Diversity. This includes the selection of functional traits and calculation of Functional Diversity Indexes.

The course provides essential skills and knowledge that enable the participants to develop climate change adaptation strategies.

Logótipo do evento

The Symposium will gather the latest research on changes in marine connectivity under anthropogenic pressures.

The objective of this course is to provide participants with basic knowledge on a) the fundamental aspects of experimental design and b) workflows, platforms and tools to increase reproducibility at all scientific levels.

In this course we will provide advanced hands-on training on some of the most used technological tools in field biology.