Por Samuel Sánchez (Institute for Bioengineering of Catalonia, Institute for Science and Technology, Catalan Institute for Research and Advanced Studies, Spain).

(Bio)Engineering out of the equilibrium systems which resemble living microswimmers is not a trivial task. Chemists have made use of catalysis to generate enough force at the nanoscale to achieve that goal and self-propel nano- and micro-particles as “nanobots”. Over the last few years, we have studied the motion of Pt-Silica “Janus microbots” as a model system of artificial active matter. We achieved motion control, transport in microfluidic devices and also guidance - single and collective- using small microfabricated features thanks to the interaction of the microparticles with nearby walls.

With the goal of developing small vehicles that can eventually be applied in nanomedicine, alternative fuel-particle systems need to be developed. An elegant way to replicate biological swimmers is to use enzymes as bio-catalysts as they are abundant in nature, consume bio- available fuels, are biocompatible and in some cases, highly efficient. In my talk, I will present how we bioengineer hybrid nanobots combining the best from the two worlds: biology (enzymes) and (nano)technology (nano- micro-particles) providing swimming capabilities, biocompatibility, remote control, multifunctionality and actuation. I will present some of the proof-of-concept applications such as the efficient transport of drugs into cancer cells and spheroids, sensing capabilities and the use of molecular imaging techniques for their tracking and localization both in vitro and in vivo in confined spaces like mice bladder.

Zoom

Topic: CFTC weekly seminar

Time: Mar 18, 2021 10:00 AM Lisbon

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