BioSys/BioISI Research Seminar

Epithelial-Mesenchymal Plasticity in Breast Cancer Metastasis

Sala 1.3.15, FCUL, Lisboa

Jonas Fuxe
Dept. of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Sweden

Metastatic spread of cancer cells to vital organs is the major cause of death in cancer. Understanding the metastatic process has remained an elusive task and consequently, there is a lack of treatments that target and inhibit metastasis. Despite intense research, our knowledge of how and when cancer cells disseminate are limited. In fact, even the perhaps most fundamental question - why cancer cells metastasize, remains to be answered. Recent data show that epithelial-mesenchymal transition (EMT), a latent developmental process, is re-activated during cancer and chronic inflammation. Cytokines, such as transforming growth factor beta 1 (TGF-b1) can trigger EMT, whereby cancer cells lose epithelial, and gain migratory properties. Increased levels of TGF-b1 is detected in plasma of breast cancer patients and at invasive fronts in human breast cancer tissues, and correlates with the presence of lymph node metastasis. Breast cancer cells undergoing EMT also acquire cancer stem cell-like properties. TGF-b1 signaling towards EMT involves both Smaddependent, and -independent pathways including Akt and p38 MAPK. Blocking EMT, or its consequences, would be attractive as a novel type of anti-metastatic cancer treatment. Yet, the mechanisms of how EMT is induced and importantly, the functionality of EMT during the different steps of the metastatic cascade are not clear. We have established an interdisciplinary research program to elucidate the role of EMT as a link between cancer and inflammation.

BioISI - Instituto de Biossistemas e Ciências Integrativas

Lisbon Workshop Series - AI Aesthetics and Philosophy of Technology.

Mathematical Logic Seminar, por António Marques Fernandes (IST - Universidade de Lisboa).

Data Science Seminar, por Daniel Gonçalves (LASIGE/DI-FCUL).

Geometry & Physics Seminar, por Davide Guzzetti (SISSA, Italy).

Talk @DI, por Luís Pinto (DI, Ciências ULisboa).

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Ciclo de Palestras de Outono do GAPsi.

Ação de formação para docentes.

Currently, climate changes or alterations are known to be reflected on the stable isotope ratios of Hydrogen, Nitrogen, Carbon, Oxygen and Sulphur present in atmospheric gas forms, fresh or ocean water, as well as in plants and animals and organic matter in the soil.

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Ciclo de Palestras de Outono do GAPsi.

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A campanha visa recolher o maior número possível de pilhas, baterias, lâmpadas, tinteiros e equipamentos elétricos usados.

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Candidaturas online de 1 a 31 de dezembro de 2022.

The objective of this course is to acquire knowledge regarding bioinformatic tools available to predict nucleic acid (RNA, DNA or Nucleic Acids Mimics) and protein three-dimensional structure, as well as autonomy and critical thinking in the use of those tools.

Science is increasingly more present in our everyday decisions, with a fundamental role in global problems. Scientists, as the main actors in the production of scientific knowledge, have the responsibility of having an active voice in communicating this knowledge.

The course aims at introducing attendants to an updated state of the art of diversity of the soil biota and the functional roles played by soil organisms in key ecological processes.

Symbiosis is a key strategy for life on Earth. Nevertheless, although many research groups have long been committed to the study of symbiosis, its definition and functioning are not fully understood, and its ecological role and relevance are still underestimated.

This 5-day course offers to the participants a light microscopy course focusing on fluorescence microscopy techniques applied to the detection of proteins and glycans in tissue samples and cell cultures.

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Candidaturas ao prémio (versões preliminares dos artigos) até 28 de fevereiro de 2023.

This course aims to explore ways of communicating science to non-specialized audiences, such as policy makers, industry, general public (including students and teachers), through their engagement and participation in citizen science activities.

A 19 de abril de 2023 celebra-se o 112.º aniversário da Faculdade de Ciências da Universidade de Lisboa.

The objective of this course is to provide students with basic knowledge of R programming, allowing them to manipulate and visualize data with R.

The objective of this course is to provide students with statistical knowledge and tools to manipulate, analyze and visualize biological data with R. Introduction to modeling, simulations and Bayesian statistics.

Under the general framework of Global Change Ecology, the goal of this course is to provide the participants with the most recent and practical knowledge on the use of Functional Diversity. This includes the selection of functional traits and calculation of Functional Diversity Indexes.

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Abstract submission will close on 14 November 2022.

The course provides essential skills and knowledge that enable the participants to develop climate change adaptation strategies.

The objective of this course is to provide participants with basic knowledge on a) the fundamental aspects of experimental design and b) workflows, platforms and tools to increase reproducibility at all scientific levels.