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FEDERICO HERRERA

Contactos

Departamento de Química e Bioquímica

Sala/Gabinete 8.4.59 / 8.4.54
Ext. Principal 28459 / 28454
Telefone Direto 925009786
Extensão pessoal 28454
Email fherrera@ciencias.ulisboa.pt
Página Pessoal
Carreira Docente Universitário
Categoria Professor Auxiliar

Indicadores

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CiênciaVitae

Palavras Chave

  • Doenças neurodegenerativas
  • Complementação proteica
  • Modificações pós-traducionais
  • Via de JAK/STAT3
  • Filamentos intermédios

Keywords

  • Neurodegenerative disorders
  • Protein complementation
  • Post-translational modifications
  • JAK/STAT3 pathway
  • Intermediate filaments
Interesses Científicos

Doenças neurodegenerativas raras, microscopia, citoesqueleto, agregação proteica, interações proteina-proteina

Scientific Interests

Our group is interested in the physiological and pathological functions of proteins related to damage in the central nervous system (CNS), and how post-translational modifications influence them. We are currently concentrating efforts on the role of astroglia in CNS pathologies and the intracellular pathways that control it, such as the JAK/STAT3 pathway. We are also interested in protein complementation, a fundamental property observed in many proteins, such as ubiquitin, the green fluorescent protein family, thymidine kinase or luciferase. These proteins can be split in two or more fragments that are not functional, but that recover their function when they are brought back together by non-covalent bonds. Protein complementation could be used as a therapeutical tool for human pathologies involving protein truncations or mutations, as well as a biotechnological tool for research purposes.

Publicações selecionadas
  • Murtinheira, F.; Migueis, M.; Letra-Vilela, R.; Diallo, M.; Quezada, A.; Valente, C.A.; Oliva, A.; Rodriguez, C.; Martin, V.; Herrera, F. Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments. Cells 2022, 11, 299. https://doi.org/10.3390/cells11020299
  • Moreira GG, Cantrelle FX, Quezada A, Carvalho FS, Cristóvão JS, Sengupta U, Puangmalai N, Carapeto AP, Rodrigues MS, Cardoso I, Fritz G, Herrera F, Kayed R, Landrieu I, Gomes CM (2021). Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding. Nat Commun 12, 6292 (2021). https://doi.org/10.1038/s41467-021-26584-2.
  • Letra-Vilela R#, Cardoso B#, Silva-Almeida C, Rocha AM, Murtinheira F, Branco-Santos J, Rodriguez C, Martin V, Santa-Marta M, Herrera F (2020). Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers? FASEB Bioadv. 2020 Jan 27;2(2):116-125. doi: 10.1096/fba.2019-00049. #, equal contribution.
  • Letra-Vilela, R.#, Quiteres, R.#, Murtinheira, F., Crevenna, A., Hensel, Z., Herrera F (2020). New tools for the visualization of glial fibrillary acidic protein in living cells. Experimental Results, 1, E4. doi:10.1017/exp.2020.1. #, equal contribution.
  • Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity. Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. PMID: 28934390

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