BioISI Post Graduate Seminars

Auditório da FCiências.ID, Lisboa

Por Tânia Marques e Diana Pimentel (BioSYS PhD Program).


An integrative approach to tissue-specific effects of miRNA regulatory networks - Tânia Marques

MicroRNAs or miRNAs are small noncoding RNAs with a major role in post-transcriptional regulation of gene expression. miRNAs become part of the RISC complex which binds to miRNA responsive elements located predominantly in the 3’UTRs of target mRNAs through base-pairing interactions involving the miRNA seed sequence leading to degradation or translational inhibition of the mRNA molecule. Even though the basic mechanisms for miRNA action have been described, we are still unable to efficiently predict the impact of these molecules on cellular function. miR function has been proposed to be regulated by endogenous competing RNAs, including both coding and noncoding RNA molecules. This suggests that the ability of a given miRNA to act upon a target is dynamically influenced by the transcriptome environment it is in, in addition to the binding affinity it displays to different targets. Thus, when predicting targets for a miRNA, the context in which it is expressed needs to be accounted for. The aim of this work is to comprehensively understand the interaction dynamics between microRNAs and their target transcriptome across different conditions. This will be achieved by dissecting miRNA regulatory networks through correlation analysis between miRNA, mRNA and predicted targets in public datasets for different tissues and conditions.

Transcriptional and metabolic regulation of grape berry metabolism upon powdery mildew infection - Diana Pimentel

Grapevine (Vitis vinifera L.) is very susceptible to several diseases and one of the most problematic is powdery mildew (PM). PM is caused by the obligate biotrophic fungus Erysiphe necator and it affects grapevine yield and berry quality. In this study, naturally infected and control grapes from Carignan variety were collected at green (EL33) and véraison (EL35) stages and metabolic and transcriptomic changes upon PM infection of susceptible grapes were analyzed. Metabolic profiling of control and infected berries was performed by gas chromatography coupled to electron impact ionization/time-of-flight mass spectrometry (GC-EI/TOF-MS) and by solid phase microextraction (SPME) associated with GC-EI-MS. Thirty-six metabolites showed differential content comparing either infected and control samples or green and véraison stages. Among these, twenty were shown to be positive markers of infection including five metabolites that were undetected in control samples. RNAseq analysis was performed to access the expression profile of PM infected and control berries at both stages and 4275 genes were identified as differentially expressed due to infection and/or ripening, and they are mainly associated with response to biotic stress, secondary metabolism (phenylpropanoid and terpene pathways) and hormone metabolism, including salicylic acid and jasmonates. Altogether, these data suggest a metabolic and transcriptomic reprogramming upon infection with PM in particular at green stage.

17h00
BioISI - Instituto de Biossistemas e Ciências Integrativas

Por Gabrielle Nornberg (University of São Paulo and Sapienza Università di Roma).

Afonso Luís Moreira Dimas Martins defende a dissertação "Modelling Influenza Strain Competition Dynamics and Transmission Fitness".

Orientação: Maria Helena Mouriño Nunes, Erida Gjini (Instituto Gulbenkian de Ciência).

Imagem ilustrativa das exposições "The Eagle Has Landed" e "E3 - Einstein, Eddington e o Eclipse"

A exposição The Eagle Has Landed - Viagens à Lua comemora o meio século da alunagem da Missão Apollo 11.

Ana Beatriz Gomes Ferreira defende a dissertação "Dinâmica sedimentar e morfológica do campo de dunas da Crismina-Guincho".

Júri:

Ana Sofia Antunes Silvestre defende a dissertação "Developing a method for a rapid immunoassay Kit to detect Salmonella spp. bacteria".

Isa Soraia Batista Moutinho defende a dissertação "Desenvolvimento de anticorpos bi-específicos para o tratamento do VIH-1".

Imagem ilustrativa do evento, acompanhada de várias informações (título, orador, dia, hora, local e entidades participantes)

Por Rui Agostinho (IA - Instituto de Astrofísica e Ciências do Espaço / FCUL - Faculdade de Ciências da Universidade de Lisboa).

Francisco Filipe Coroado Santos defende a dissertação "Peopling of Greek Islands: Understanding the Bronze Age transition with Ancient Genomes".

Júri das provas:

Candidaturas Erasmus

De 1 a 31 de dezembro, candidata-te a um período de estudos ou investigação, ao abrigo do Programa Erasmus+.

Sofia Margarida Serafim Carvalho Xavier Valente defende a dissertação "Identification and manipulation of Cystatins to Control Mycobacterium tuberculosis Infection of Human Macrophages".

Carolina Cristiano de Almeida defende a dissertação "Structural and functional diversity of the diazotrophic community in xeric ecosystems: response to nitrogen availability".

Inscrições até 2 de janeiro de 2020, mediante envio de formulário de inscrição preenchido e comprovativo de pagamento para

Imagem ilustrativa dos cursos avançados cE3c 2019/2020

This course introduces the field of island biogeography, a discipline that has long influenced other research areas such as macroecology, community ecology, evolution and conservation biology.

Imagem ilustrativa dos cursos avançados cE3c 2019/2020

Deadline for Applications: November 22nd, 2019.

Curso de introdução ao software R, lecionado em 4 módulos a decorrer nos dias 28 de janeiro e 4, 11 e 18 de fevereiro.

 

Programa:

Título do evento, sobre uma fotografia de uma aluna a utilizar binóculos

A Universidade de Lisboa preparou diversas atividades para te ajudar a perceber qual o teu futuro profissional. Vem descobrir a ULisboa!

Days in Logic will take place in Lisbon (FCUL) in January 30 and 31 and in the morning of February 1, 2020.

Logótipo Portugal 2020, sobre um fundo branco

No âmbito do Portugal 2020 encontra-se a decorrer o prazo de candidatura ao Sistema de Incentivos à Investigação e Desenvolvimento Tecnológico (SI I&DT) para projetos a desenvolver em Copromoção no âmbito da I&D Empresarial.

We begin with an introduction to R and provide a protocol for data exploration to avoid common statistical problems. We will discuss how to detect outliers, deal with collinearity and transformations.

Imagem ilustrativa do evento, acompanhada de várias informações (título, slogan e entidades promotoras)

The Doctoral INPhINIT Fellowship programme aims to support the best scientific talent - of any nationality - and foster innovative and high-quality research in Spain and Portugal by rec

As Jornadas de Estatística Médica (1.ª edição) destinam-se a todos os interessados em aplicações da Estatística nas áreas de Medicina, Enfermagem e Indústria Farmacêutica.

 

Datas importantes:

Título, data e localização do evento, sobre uma fotografia da cidade de Lisboa

The CSSC workshop is focused on the silicon material and the substrate with strong attention on crystallization. The SiMat workshop focuses on the interface between silicon materials and cell and module technologies.

No seguimento da 1.ª conferência (ICUR2016), serão abordados temas relacionados com a gestão, avaliação e mitigação de riscos naturais e tecnológicos, assim como o seu impacto na saúde e nas sociedades.

Imagem alusiva à Escola de Verão de Energia

Imagina que era possível experimentar um curso universitário antes de concorreres ao ensino superior.

Imagem ilustrativa do evento, acompanhada de várias informações (título e datas)

PANIC2020 will be held in Lisbon from August 31 to September 4, 2020.

This conference is the 22nd in the series of triennial conferences which bring together the Particle and Nuclear Physics communities.

Páginas