Federico Herrera


Instituto de Biosistemas e Ciências Integrativas

Sala/Gabinete 8.2.54
Ext. Principal 28254 Ext. Alt 28175
Telefone Direto 925009786
Email fherrera@ciencias.ulisboa.pt

Carreira Docente Universitário
Categoria Professor Auxiliar

Currículo Resumido


2001-2005 Ph.D. degree, Dep. of Morphology and Cell Biology, School of Medicine, University of Oviedo, Oviedo, Spain.

1999-2001 M.Sc. degree, Dep. of Morphology and Cell Biology, School of Medicine, University of Oviedo, Oviedo, Spain.

1995-1999 B.Sc. degree in Biology, University of Oviedo, Oviedo, Spain.


2019-present Auxiliary Professor, Head of the Cellular Structure and Dynamics Laboratory, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.

2014-2018 Laboratory Head (FCT investigator 2013, IF/00094/2013), Cellular Structure and Dynamics Laboratory, Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal.

2012 Research Associate (FUTTALENT), Dep. of Morphology and Cell Biology, School of Medicine, University of Oviedo, Oviedo, Spain.

2010-2013 Research Associate, Instituto de Medicina Molecular, Lisbon, Portugal.

2006-2009 Research Associate, The Salk Institute, La Jolla, CA, USA.

2005-2006 Postdoctoral Researcher, Dep. of Morphology and Cell Biology, School of Medicine, University of Oviedo, Oviedo, Spain.


2013 FCT Investigator, Fundação para a Ciência e a Tecnologia (IF/00094/2013), Portugal.

2012 FUTTALENT award, Campus of International Excellence, University of Oviedo, Spain.

2010-2013 Postdoctoral research fellowship, Fundação para a Ciência e a Tecnologia (SFRH/BPD/63530/2009), Portugal.

2009 Pioneer Postdoctoral Scholar Award, The Salk Institute for Biological Studies, USA.

2008-2009 Postdoctoral research fellowship, Bundy Foundation for Alzheimer’s Research, USA.

2006-2008 Postdoctoral research fellowship, Ministry of Health and Consumption/CSIC/The Salk Institute (Exp. Nr. SALK06/02), Spain.

2006 Fulbright postdoctoral research fellowship, Ministry of Education and Science, rejected for incompatibility with fellowship SALK06/02, Spain.

2006 Extraordinary Award to the Best PhD Thesis presented at the University of Oviedo in 2005, Spain.


2018-2021 Mechanistic and optogenetic control of astroglia for neural repair (FCT, PTDC/MED-NEU/31417/2017). Role: Principal Investigator. Funds: 239.000 euros


ORCID: https://orcid.org/0000-0002-9596-9353

GOOGLE SCHOLAR: https://scholar.google.com/citations?hl=es&user=t8Yz3t4AAAAJ

Scientific Interests

Our group is interested in the physiological and pathological functions of proteins related to damage in the central nervous system (CNS), and how post-translational modifications influence them. We are currently concentrating efforts on the role of astroglia in CNS pathologies and the intracellular pathways that control it, such as the JAK/STAT3 pathway.

We are also interested in protein complementation, a fundamental property observed in many proteins, such as ubiquitin, the green fluorescent protein family, thymidine kinase or luciferase. These proteins can be split in two or more fragments that are not functional, but that recover their function when they are brought back together by non-covalent bonds. Protein complementation could be used as a therapeutical tool for human pathologies involving protein truncations or mutations, as well as a biotechnological tool for research purposes.

Publicações selecionadas
  • Letra-Vilela R#, Cardoso B#, Silva-Almeida C, Rocha AM, Murtinheira F, Branco-Santos J, Rodriguez C, Martin V, Santa-Marta M and Herrera F* (2019). Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers?. Accepted in FASEB Bioadvances (Open Access). *, corresponding author; #, equal contribution.
  • Letra-Vilela R#, Quiteres R#, Murtinheira F, Crevenna A, Hensel Z* and Herrera F* (2019). New tools for the visualization of glial fibrillary acidic protein in living cells. Accepted in Experimental Results (Cambridge University Press, Open Acess). *, corresponding author; #, equal contribution.
  • Leitão MIPS, Herrera F, Petronilho A. N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity. ACS Omega. 2018 Nov 30;3(11):15653-15656. doi: 10.1021/acsomega.8b02387. Epub 2018 Nov 16. PMID: 30556009
  • Branco-Santos J, Herrera F, Poças GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity. Hum Mol Genet. 2017 Oct 1;26(19):3763-3775. doi: 10.1093/hmg/ddx260. PMID: 28934390
  • Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F. Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Mol Cell Endocrinol. 2016 Oct 15;434:238-49. doi: 10.1016/j.mce.2016.07.012. Epub 2016 Jul 9. PMID: 27402602

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