- Entrega de péptidos ao SNC
- Disfunção de domínios membranares na epileptogénese e na ELTM
- Terapias de recuperação cognitiva
- Circuitos monoaminergicos na ELTM e no envelhecimento
ContactosCentro de Química e Bioquímica
Ext. Principal 28620 Ext. Alt 28542
Telefone Direto 217500991
Categoria Investigador Doutorado Contratado ao Abrigo do DL57
- Peptide delivery to the CNS
- Membrane domain disfunction in epileptogenesis and MTLE
- Regnitive recovery therapies
- Monoaminergic circuits in MTLE and aging
Diana Cunha-Reis is currently a researcher at Biosystems and Integrative Sciences Institute and Centro de Química e Bioquímica, DQB, Faculty of Sciences, University of Lisbon, Portugal. She is coordinator and lecturer of the Physiology course, Biochemistry BSc degree, FCUL.
She graduated in Biochemistry in 1999 at the Faculty of Sciences, University of Lisbon and completed her PhD in Biomedical Sciences, Neuroscience Specialty at the Faculty of Medicine, University of Lisbon, Portugal in 2007.
As part of her PhD studies she was a visiting fellow at the Rudolph-Boehm Institute for Pharmacology and Toxicology, Faculty of Medicine, University of Leipzig, Germany and Swammerdam Institute for Neurobiology, Faculty of Biology, University of Amsterdam, The Netherlands.
From 2007 to 2010 she was a postdoctoral research fellow at the Neuroscience unit, Instituto de Medicina Molecular, University of Lisbon, Portugal.
From January 2012 to December 2016 Diana Cunha-Reis was a postdoctoral researcher fellow at Centro de Química e Bioquímica, DQB, Fac. Ciências and Instituto de Medicina Molecular, Fac. Medicina University of Lisbon, Portugal.
From September 2012 to September 2014 Diana Cunha-Reis was assistant professor in Human Physiology (course responsible) at ECTS, Universidade Lusófona de Humanidades e Tecnologias, Lisbon, Portugal.
From January 2017 to June 2019 Diana Cunha-Reis was a postdoctoral researcher at Centro de Química e Bioquímica, DQB, , Faculty of Sciences, University of Lisbon, Portugal and Clínica Universitária de Neurologia, Fac. Medicina, University of Lisbon, Portugal.
She currently studies: 1) The value of VPAC1 VIP receptor antagonists in reversing the plastic changes following seizures and its contributions to the epileptogenesis process in TLE; 2) Cognitive rescue in TLE and aging using novelty training strategies and VIP receptor ligands; 3) the changes in membrane lipid composition and lipid raft dynamics in TLE and the ability of the ketogenic diet therapy to reverse them.
- 1. *Cunha-Reis, D.; Caulino-Rocha, A. (2020) VIP modulation of hippocampal synaptic plasticity: a role for VIP receptors as therapeutic targets in cognitive decline and mesial temporal lobe epilepsy, Fr Cell Neurosci., in the press. (mini-review) doi: 10.3389/fncel.2020.00153
- Aidil-Carvalho M.F.; Carmo A.J.S.; Ribeiro, J.A. and *Cunha-Reis, D. (2017) Mismatch novelty exploration training enhances hippocampal synaptic plasticity: a tool for cognitive stimulation? Neurobiol. Learn. Mem., 145:240-250. doi: 10.1016/j.nlm.2017.09.004. PMID 28893669.
- Cunha-Reis, D.; Ribeiro, J.A., de Almeida R.F. and Sebastião, A.M. (2017) VPAC1 and VPAC2 receptor opposed modulation of GABA release from hippocampal nerve terminals involves multiple signaling pathways, Br. J. Pharmacol., 174:4725-4737. doi: 10.1111/bph.14051. PMID: 28945273.
- Cunha-Reis, D.; Aidil-Carvalho M.F. and Ribeiro, J.A. (2014) Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors, Hippocampus, 24:1353–1363. doi: 10.1002/hipo.22316. PMID 24935659
- Cunha-Reis, D.; Sebastião, A.M. Wirkner, K.; Illes, P. and Ribeiro, J.A. (2004) VIP enhances both pre- and post-synaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells, Br. J. Pharmacol., 143, 733-744. doi: 10.1038/sj.bjp.0705989. PMID: 15504757.