- Entrega de péptidos ao SNC
- Disfunção de domínios membranares na epileptogénese e na ELTM
- Terapias de recuperação cognitiva
- Circuitos monoaminergicos na ELTM e no envelhecimento
DIANA CUNHA REIS
Contactos
Departamento de Biologia VegetalSala/Gabinete 2.1.50 / 8.6.20
Ext. Principal 522150 / 528620
Telefone Direto 217500991
Extensão pessoal 528620
Email dcreis@ciencias.ulisboa.pt
Carreira Investigação
Categoria Investigador FCT nível inicial
Indicadores
ResearcherIDOrcid
Scopus
Google Scholar
CiênciaVitae
Palavras Chave
Keywords
- Peptide delivery to the CNS
- Membrane domain disfunction in epileptogenesis and MTLE
- Regnitive recovery therapies
- Monoaminergic circuits in MTLE and aging
Interesses Científicos
Comunicação sináptica; Plasticidade sináptica; Bioquímica de membranas; adaptações na cognição e terapêuticas; envelhecimento e disfunção sináptica; epilepsia e domínios lipídicos.
Scientific Interests
Synaptic signaling; Synaptic plasticity; Membrane biochemistry; cognitive adaptations and therapy; aging and synaptic disfunction; epilepsy and lipid rafts.
Publicações selecionadas
- Carvalho-Rosa JD, Rodrigues NC, Silva-Cruz A, Vaz SH and *Cunha-Reis D (2023) Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity? Front Cell Neurosci., 17:1117697. doi: 10.3389/fncel.2023.1117697.
- Caulino-Rocha, A.; Rodrigues, N.C.; Ribeiro, J.A. and *Cunha-Reis, D. (2022) Endogenous VIP VPAC1 receptor activation modulates theta burst induced LTP in the hippocampus: transduction pathways and GABAergic mechanisms, Biology, 11(5):627, doi: 10.3390/biology11050627.
- *Cunha-Reis, D.; Caulino-Rocha, A. and Correia-de-Sá P (2021) VIPergic neuroprotection in epileptogenesis: challenges and opportunities, Pharmacol. Res., 164:105356. (review) doi: 10.1016/j.phrs.2020.105356.
- *Cunha-Reis, D. and Caulino-Rocha, A. (2020) VIP modulation of hippocampal synaptic plasticity: a role for VIP receptors as therapeutic targets in cognitive decline and mesial temporal lobe epilepsy, Front. Cell. Neurosci., 14:153. (review) doi: 10.3389/fncel.2020.00153.
- Cunha-Reis, D.; Ribeiro, J.A., de Almeida R.F. and Sebastião, A.M. (2017) VPAC1 and VPAC2 receptor opposed modulation of GABA release from hippocampal nerve terminals involves multiple signaling pathways, Br. J. Pharmacol., 174:4725-4737. doi: 10.1111/bph.14051. PMID: 28945273.