Bárbara Henriques


Departamento de Química e Bioquímica

Sala/Gabinete 8.5.56 / 8.5.57
Ext. Principal 28556 / 528557
Telefone Direto 217500256
Email bjhenriques@ciencias.ulisboa.pt

Carreira Investigação
Categoria Investigador Auxiliar


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Scientific Interests

The main topic of my research is the study of human proteins involved in metabolic conformational diseases, which become misfolded and/or inactive due to mutations or adverse cellular conditions. In particular, one of my current interest is related to understanding mitochondria regulation by non-enzymatic Post-Translational Modifications (PTMs) and their impact in metabolic disorders. To undertake our goals, we use a complementary set of tools, ranging from biochemical and molecular biology to biophysical, spectroscopic and proteomics techniques.

Publicações selecionadas
  • Ribeiro, JV, Lucas TG, Bross P, Gomes CM and Henriques BJ (2019) “Potential complementation effects of two disease-associated mutations in tetrameric glutaryl-CoA dehydrogenase is due to inter subunit stability-activity counterbalance” BBA - Proteins and Proteomics doi: 10.1016/j.bbapap.2019.140269
  • Henriques, BJ, Lucas, TG, Martins, E, Gaspar, A, Bandeira, A, Nogueira, C, Brandão, Rocha, H, Vilarinho, L and Gomes, CM, (2019) “Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency” Current Molecular Medicine 19(7): 487-493 DOI: 10.2174/1566524019666190507114748
  • Henriques, B. J., Lucas, T. G., & Gomes, C. M. (2016). Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders. Curr Drug Targets, 17(13), 1527-1534
  • Ribeiro JV, Gomes CM and Henriques BJ. "Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation—Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients" Int. J. Mol. Sci. 2020, 21(19), 7063 doi:10.3390/ijms21197063
  • Henriques BJ.; Olsen RKJ, Gomes CM, Bross P "Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease". Gene 776 (2021): 145407. doi:10.1016/j.gene.2021.145407

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