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Bárbara J. Henriques

Contactos

Instituto de Biosistemas e Ciências Integrativas

Sala/Gabinete 8.5.59/8.5.56
Ext. Principal 28569 Ext. Alt 28556
Telefone Direto 217500256
Email bjhenriques@ciencias.ulisboa.pt
Carreira Investigacao
Categoria Investigador Doutorado Contratado ao Abrigo do DL57

Indicadores

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Palavras Chave

  • Folding & Misfolding proteico
  • Doenças metabólicas
  • Modificações pós-traducionais

Keywords

  • Protein Folding & Misfolding
  • Inborn errors of metabolism
  • Post-translational modification (PTM)
Scientific Interests

The main topic of my research is the study of human proteins involved in metabolic conformational diseases, which become misfolded and/or inactive due to mutations or adverse cellular conditions. In particular, one of my current interest is related to understanding mitochondria regulation by non-enzymatic Post-Translational Modifications (PTMs) and their impact in metabolic disorders. To undertake our goals, we use a complementary set of tools, ranging from biochemical and molecular biology to biophysical, spectroscopic and proteomics techniques.

Publicações selecionadas
  • Ribeiro, JV, Lucas TG, Bross P, Gomes CM and Henriques BJ (2019) “Potential complementation effects of two disease-associated mutations in tetrameric glutaryl-CoA dehydrogenase is due to inter subunit stability-activity counterbalance” BBA - Proteins and Proteomics doi: 10.1016/j.bbapap.2019.140269
  • Henriques, BJ, Lucas, TG, Martins, E, Gaspar, A, Bandeira, A, Nogueira, C, Brandão, Rocha, H, Vilarinho, L and Gomes, CM, (2019) “Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency” Current Molecular Medicine 19(7): 487-493 DOI: 10.2174/1566524019666190507114748
  • Henriques, B. J., Lucas, T. G., & Gomes, C. M. (2016). Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders. Curr Drug Targets, 17(13), 1527-1534
  • Henriques, B. J., Lucas, T. G., Rodrigues, J. V., Frederiksen, J. H., Teixeira, M. S., Tiranti, V., . . . Gomes, C. M. (2014). Ethylmalonic encephalopathy ETHE1 R163W/R163Q mutations alter protein stability and redox properties of the iron centre. PLoS One, 9(9), e107157. doi: 10.1371/journal.pone.0107157
  • Henriques BJ, Bross P, and Gomes CM (2010) “Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency” BBA -Molecular Basis of Disease, 1802 (11):1070-1077 DOI: 10.1016/J.BBADIS.2010.07.015

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