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Ana Coutinho

Contactos

Departamento de Química e Bioquímica

Sala/Gabinete 8.4.57
Ext. Principal 28447
Telefone Direto 217500930
Email aicoutinho@ciencias.ulisboa.pt
Carreira Docente Universitário
Categoria Professor Auxiliar

Indicadores

ResearcherID
Orcid

Palavras Chave

  • Interacção lípido-proteína
  • Biofísica de membranas
  • Espectroscopia de fluorescência
  • Péptidos amiloidogénicos

Keywords

  • Lipid-protein interaction
  • Membrane biophysics
  • Fluorescence spectroscopy
  • Amyloidogenic peptides
Currículo Resumido

Ana Coutinho is an Assistant Professor at the Department of Chemistry and Biochemistry, Faculdade de Ciências da Universidade de Lisboa (FCUL). She obtained a licenciatura in Biochemistry from FCUL and her PhD in Biochemistry (2000) from Universidade de Lisboa. She did postdoctoral studies at the Instituto de Química-Física "Rocasolano" (Dr. M. Pilar Lillo, Madrid, Spain).

Scientific Interests

The influence of lipid membranes on the molecular mechanism of fibril formation by amyloidogenic proteins/peptides.

Using fluorescence resonance energy transfer (FRET) to study the conformational dynamics of membrane proteins.

Publicações selecionadas
  • Fernandes, F, Coutinho A, Prieto M, Loura LMS (2015) Electrostatically driven lipid-protein interaction: Answers from FRET, Biochim. Biophys. Acta – Biomembranes (Special Issue: “Lipid-Protein Interactions”, 1848(9), 1837-1848, doi: 10.1016/j.bbamem.2015.02.023
  • Amaro M, Šachl R, Jurkiewicz P, Coutinho A, Prieto M, Hof M (2014) Time-Resolved Fluorescence in Lipid Bilayers: Selected Applications and Advantages over Steady-State, Biophys. J., 107(12), 2751-2760, doi: 10.1016/j.bpj.2014.10.058
  • Melo AM, Fedorov A, Prieto M, Coutinho A (2014) Exploring homo-FRET to quantify the oligomer stoichiometry of membrane-bound proteins involved in a cooperative partition equilibrium, Phys. Chem. Chem. Phys., 16(34), 18105-18117, doi: 10.1039/c4cp00060a
  • Melo AM, Ricardo JC, Fedorov A, Prieto M, Coutinho A. (2013) Fluorescence detection of lipid-induced oligomeric intermediates involved in lysozyme “amyloid-like” fiber formation driven by anionic membranes, J. Phys. Chem B, 117, 2906-2917, doi: 10.1021/jp310396v
  • Melo AM, Prieto M, Coutinho A (2011) The effect of variable liposome brightness on quantifying lipid-protein interactions using fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1808,2559-2568. doi: 10.1016/j.bbamem.2011.06.001

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