- Doença humana
- Fibrose quística
- Folding de proeínas
- Teranóstico
- Genómica funcional
- Descoberta de fármacos
Margarida D Amaral
Contactos
Departamento de Química e BioquímicaSala/Gabinete 8.3.66 / 8.3.66
Ext. Principal 28 366 / 28366
Telefone Direto 35121750 08 61
Email msamaral@ciencias.ulisboa.pt
Carreira Docente Universitário
Categoria Professor Catedrático
Indicadores
ResearcherIDOrcid
Scopus
CiênciaVitae
Palavras Chave
Keywords
- Human disease
- Cystic Fibrosis
- Protein folding
- Theranostics
- Functional genomics
- Drug Discovery
Currículo Resumido
Margarida D. Amaral is Full Professor at the Faculty of Sciences of the University of Lisboa and leads a research group at BioISI research centre, which she founded. Her lab investigates the molecular mechanisms of Cystic Fibrosis (CF), using transcriptomics, proteomics, and high-throughput screens, with a recent focus on CF-related cancer. Their findings contribute to advances in CF diagnosis, prognosis, drug discovery, and theranostics. An EMBL and IGC alumna, she is a member of EMBO and of the Lisboa Academy of Sciences and has received prestigious prizes, including the ECFS Annual Award and the Pfizer Award (Portugal). She held a visiting professorship in Brazil and currently in China.
Interesses Científicos
Margarida D. Amaral é Professora Catedrática na Faculdade de Ciências da Universidade de Lisboa onde lidera um grupo de investigação no centro BioISI, que fundou. O seu laboratório investiga os mecanismos moleculares da Fibrose Quística (FQ), utilizando abordagens como transcritómica, proteómica e screens de alto rendimento, e, mais recentemente, com um foco recente no cancro associado à FQ. As suas descobertas contribuem para avanços no diagnóstico, prognóstico, descoberta de fármacos e teranóstico da FQ. É alumna do EMBL e do IGC, é membro da EMBO e da Academia das Ciências de Lisboa, tendo recebido prémios de prestígio, incluindo o Prémio Anual da ECFS e o Prémio Pfizer (Portugal). Foi professora visitante no Brasil e na China.
Scientific Interests
Margarida D. Amaral is Full Professor at the Faculty of Sciences of the University of Lisboa and leads a research group at BioISI research centre, which she founded. Her lab investigates the molecular mechanisms of Cystic Fibrosis (CF), using transcriptomics, proteomics, and high-throughput screens, with a recent focus on CF-related cancer. Their findings contribute to advances in CF diagnosis, prognosis, drug discovery, and theranostics. An EMBL and IGC alumna, she is a member of EMBO and of the Lisboa Academy of Sciences and has received prestigious prizes, including the ECFS Annual Award and the Pfizer Award (Portugal). She held a visiting professorship in Brazil and currently in China.
Publicações selecionadas
- 1. Botelho HM, Uliyakina I, Awatade NT, Proença MC, Tischer C, Sirianant L, Kunzelmann K, Pepperkok P, Amaral MD (2015) Protein Traffic Disorders: an Effective High-Throughput Fluorescence Microscopy Pipeline for Drug Discovery. Sci Rep 5:9038. [PMID: 25762484].
- 2. Almaça J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Hériché JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD (2013) High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets. Cell 154: 1390-1400. [PMID: 24034256].
- 3. Sosnay PR, Siklosi KR, Van Goor F, Kaniecki K, Corey M, Ramalho AS, Amaral MD, Dorfman R, Masica DL, Karchin R, Sharma N, Lewis MH, Yu H, Thomas PJ, Millen L, Zielenski, J Patrinos GP, Castellani C, Rommens JM, Penland CM, Cutting GR (2013) Defining the disease-liability of mutations in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet 5: 1160-7. [PMID: 23974870].
- 4. Farinha CM, King-Underwood J, Sousa M, Correia AR, Henriques MJ, Roxo-Rosa M, Da Paula AC, Williams J, Hirst S, Gomes CM, Amaral MD (2013) Revertants, Low Temperature, and Correctors Reveal the Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction. Cell Chem Biol 20: 943-55. [PMID: 23890012].
- 5. Roxo-Rosa M, Xu Z, Schmidt A, Neto M, Cai Z, Soares CM, Sheppard DN, Amaral MD (2006) Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms. Proc Natl Acad Sci USA 103: 17891-17896. [PMID: 17098864].
Prizes and Awards
2022-10-26 - Reconhecimento da Investigação de Excelência em Ciências (Faculdade de Ciências da Universidade de Lisboa)
2022-06-28 - Prémios Científicos Universidade de Lisboa/Caixa Geral de Depósitos (Caixa Geral de Depósitos)