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Luka Clarke

Contactos

Departamento de Química e Bioquímica

Sala/Gabinete 8.2.50
Ext. Principal 28250
Email laclarke@ciencias.ulisboa.pt
Carreira Investigação
Categoria Investigador Auxiliar

Indicadores

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Palavras Chave

  • Gene Expression
  • Transcriptomics
  • Cystic Fibrosis

Keywords

  • Gene Expression
  • Transcriptomics
  • Cystic Fibrosis
Currículo Resumido

Luka Clarke studied Zoology at Bristol University, and then obtained his PhD from London University (Molecular Endocrinology). His post-doctoral work at CGH/INSA in Lisboa concerned alternative splicing of human mismatch repair genes. He later joined the Cystic Fibrosis (CF) group at the University of Lisboa, where he worked on two collaborative EU projects on the development of lab-on-a-chip systems for CF diagnosis. He was awarded a Ciencia 2008 research position at FCUL (2009-2014). He is now an invited auxiliary professor at FCUL and is currently engaged at BioISI in the study of mutation specific expression of the CFTR gene and its implications in personalized CF therapy.

Interesses Científicos

Personalized medicine

Scientific Interests

Cystic Fibrosis related gene expression; Allele-specific CFTR mRNA abundance; Personalized medicine; Omics and disease markers; Bioinformatic applications for high throughput data.

Publicações selecionadas
  • Clarke LA, Awatade NT, Felicio VM, Silva IAL, (...) Beekman J, Amaral MD (2019). The effect of PTC mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read-through therapies in cystic fibrosis. Human Mutation 40: 326-334.
  • Lamurias A, Clarke LA, Couto FM (2017). Extracting MicroRNA-Gene Relations from Biomedical Literature using Distant Supervision. PLoS ONE 12(3): e0171929.
  • Igreja SC, Clarke LA, Botelho HM, Marques L, Amaral MD (2015). Correction of a Cystic Fibrosis splicing mutation by antisense oligonucleotides. Human Mutation 37: 209–215.
  • Clarke LA, Botelho HM, Sousa L, Falcão A, & Amaral MD (2015). Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators. Genomics 106: 268-277.
  • Awatade NT, Uliyakina I, Farinha CM, Clarke LA, Mendes K, Solé A, Pastor J, Ramos MM, Amaral MD (2014). Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalised Therapy for Cystic Fibrosis. EBioMedicine 2: 147-153.

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