- Dynamic interactions and Ca(II)binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding Moreira G.G.*, Cantrelle F.-X., Quezada A., Carvalho F.S., Cristóvão J.S., Sengupta U., Puangmalai N., Carapeto A.P., Rodrigues M.S., Cardoso I., Fritz G., Herrera F., Kayed R., Landrieu I. and Gomes C.M. Nature Communications (2021) 12, 6292; https://doi.org/10.1038/s41467-021-26584-2
- Tau liquid–liquid phase separation is modulated by the Ca2+-switched chaperone activity of the S100B Moreira G.G.*, Gomes C.M., Journal of Neurochemistry (2023) 00, 01; https://doi.org/10.1111/jnc.15756
- Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution Moreira G.G.*, Cristóvão J.S., Torres V.M., Carapeto A.P., Rodrigues M.S., Landrieu I., Cordeiro C. and Gomes C.M. International Journal of Molecular Sciences (2019) 20(23), 5979; https://doi.org/10.3390/ijms20235979
- Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity Figueira A.J., Moreira G.G.*, Saavedra J., Cardoso I. and Gomes C.M. Journal of Molecular Biology (2022) 434(19), 167791; https://doi.org/10.1016/j.jmb.2022.167791
- Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation Cristóvão J.S., Moreira G.G.*, Rodrigues F.E.P., Carapeto A.P., Rodrigues M.S., Cardoso I., Ferreira A.E.N., Machuqueiro M., Fritz G. and Gomes C.M. Chemical Communications (2021) 57, 379-382; https://doi.org/10.1039/D0CC06842J
Guilherme G. Moreira
(Em Ciências até Fevereiro de 2025)
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Guilherme G. Moreira is a PhD Student at Protein Misfolding and Amyloids in Biomedicine (PMAB) group (http://folding.fc.ul.pt) at Faculty of Sciences of the University of Lisbon and affiliated to BioISI Biosystems & Integrative Sciences Institute. Born in 1995, has graduated in Biochemistry (2016) and completed his master's in Medical Biochemistry (2018) at the University of Lisbon. Guilherme started his PhD studies with an FCT PhD Studentship on the PMAB GomesLab (2021) with the project entitled The calcium-binding protein S100B as a novel chaperone preventing Tau aggregation in Alzheimer's disease. Guilherme is the first author of 3 published peer-reviewed international papers (2019, 2021 and 2023), co-author of 1 published book chapter (2020) and co-author of 2 published peer-reviewed international paper (2021 and 2022), as well as author of 19 posters and 5 oral communications presented in national and international events. Has been awarded 6 travel/accommodation and registration awards for international meetings.
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