Cláudio M. Gomes

    Contactos

    Departamento de Química e Bioquímica


    Extensão pessoal 528537
    Email cmgomes@ciencias.ulisboa.pt
    Página Pessoal

    Carreira Docente Universitário
    Categoria Professor Catedrático

    Indicadores

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    Scopus
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    CiênciaVitae

    Keywords


    Scientific Interests

    Biochemist specialised in protein folding, structural biochemistry and biophysics, investigating protein folding diseases and biochemistry of neurodegeneration


    Publicações selecionadas
    • Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity Figueira AJ, Moreira GG, Saavedra J, Cardoso I, Gomes CM* J Mol Biol. (2022) 434(19):167791 https://doi.org/10.1016/j.jmb.2022.167791
    • Dynamic interactions and Ca(II)binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding Moreira, G.G., Cantrelle, F.-X., Quezada, A., Carvalho, F.S., Cristóvão, J.S., Sengupta, U., Puangmalai, N., Carapeto, A.P., Rodrigues, M.S., Cardoso, I., Fritz, G., Herrera, F., Kayed, R., Landrieu, I., Gomes, C.M*. Nature Communications (2021) 12, 6292 https://doi.org/10.1038/s41467-021-26584-2
    • The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-beta Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation Cristovao, J.S., Figueira, A.J., Carapeto, A.P., Rodrigues, M.S., Cardoso, I., Gomes, C.M. ACS chemical neuroscience (2020) 11, 2753-2760 https://doi.org/10.1021/acschemneuro.0c00392
    • Cristóvão, J. S., and Gomes, C. M. (2019) S100 Proteins in Alzheimer’s Disease. Frontiers in Neuroscience 13
    • The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation Cristóvão, J.S., Morris, V.K., Cardoso, I., Leal, S.S., Martínez, J., Botelho, H.M., Göbl, C., David, R., Kierdorf, K., Alemi, M., Madl. T., Fritz, G., Reif, B., Gomes, C.M. Science Advances (2018) 4, eaaq1702 https://doi.org/https://doi.org/10.1126/sciadv.aaq1702

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    Prizes and Awards

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