Página Pessoal

Amélia Pilar Grases dos Santos Silva Rauter

Contactos

Departamento de Química e Bioquimica

Sala/Gabinete 8.5.60
Ext. Principal 28560 Ext. Alt 28540
Telefone Direto 217500075
Email aprauter@ciencias.ulisboa.pt

Carreira Docente Universitário
Categoria Professor Catedrático

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Currículo Resumido

Amélia Pilar Rauter, Full Professor, has her Habilitation at Faculdade de Ciências, Universidade de Lisboa (FCUL) in 2002 and her Ph.D. at Institut für Organische Chemie, Technische Universität Graz, Austria in 1982 under supervision of Prof. Dr. Hans Weidmann in the area of carbohydrate chemistry, in particular on branched hexuronolactones. As assistant professor at this University, she carried out her research on pseudo-C-nucleosides for one more year after promotion to Doktor der Technischem Wissenschaft, stated equivalent to Ph.D by the Technical University of Lisbon in 1984, when she started her carrier as Lecturer of the Faculty of Sciences, University of Lisbon. She was the founder of the Portuguese Society of Chemistry Carbohydrate Chemistry Group inn 1992, and the founder (2001) and leader of the CQB Carbohydrate Chemistry Group – FCUL, a centre of excellence of the ESF network Euroglycoforum (2009-2014), where she was executive of the interest group Glycochemistry. She is the Secretary of the European Carbohydrate Organization (ECO) since 2013, national representative of the International Carbohydrate Organisation since 1996, and the leader of the FCUL consortium, with more than thirty institutions, of the European Innovation Partnership on Active and Healthy Ageing (EIP AHA) Action Group 3, dedicated to early diagnosis and disease prevention, since 2012. She serves IUPAC as the Secretary of the Organic and Biomolecular Chemistry Division since 2016, and is national representative and Division representative at the IUPAC Division of Chemical Nomenclature and Structure Representation. Dedicated to the area of organic chemistry, in particular carbohydrate chemistry, she serves as member of the international advisory board of the European Journal of Organic Chemistry since 2013, and of other journals, and has relaunched the book series entitled “Carbohydrate Chemistry – Chemical and Biological Approaches” by invitation of the Royal Society of Chemistry, serving as Editor since 2008. Her research focuses on design and synthesis of new carbohydrate related small molecules for the prevention or treatment of diabetes, neurodegenerative diseases and infection. Member of the UL Network for Health, her research falls within the global objective of developing a creative and sustainable chemistry for a better health.


Scientific Interests

Scientific interests rely mainly within the area of Organic and Biomolecular Chemistry. Design and synthesis of new leads based on carbohydrate structures with new mechanisms of action, as well as isolation and structure elucidation of active principles from natural resources led to some promising molecules for metabolic (diabetes), degenerative diseases (Alzheimer´s and Prion diseases, cancer) and infection.


Publicações selecionadas
  • 1. A. R. Jesus, D. Vila-Viçosa, M. Machuqueiro, A. P. Marques, T. M. Dore, A. P. Rauter, Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation, J. Med. Chem. 2017, 60, 568−579 http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01134 (FI: 6.259; top 5% setembro 2017, SCImago)
  • 2. V. Cachatra, A. Almeida, J. Sardinha, S. D. Lucas, A. Gomes, P. D. Vaz, M. H. Florencio, R. Nunes, D. Vila-Viçosa, M. J. Calhorda, A. P. Rauter, Wittig Reaction: Domino Olefination and Stereoselectivity DFT Study. Synthesis of the Miharamycins’ Bicyclic Sugar Moiety, Org. Lett., 2015, 17(22), 5622-5625 http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b02849 (FI 6.579, NC: 1, top 3% setembro 2017, SCImago)
  • 3. S. Schwarz, R. Csuk, A. P. Rauter, Microwave-assisted synthesis of novel purine nucleosides as selective cholinesterase inhibitors, Org. Biomol. Chem. 2014, 12 (15), 2446 – 2456. https://doi.org/10.1039/c4ob00142g (FI 3.564, NC: 10)
  • 4. A.R. Jesus, C. Dias, A. M. Matos, R. F. M. Almeida, A. S. Viana, F. Marcelo, R. T. Ribeiro, M. P. Macedo, C. Airoldi, F. Nicotra, A. Martins, E. J. Cabrita, J. Jimenéz-Barbero, A. P. Rauter, Exploiting the Therapeutic Potential of 8-ß-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity and Molecular Interaction with IAPP and Aß1-42, J. Med. Chem. 2014, 57 (22), 9463-9472. https://doi.org/10.1021/jm501069h (FI: 6.259, NC: 10, top 5% setembro 2017, SCImago)
  • 5. F. Marcelo, J. Jimenez-Barbero, J. Marrot, A. P. Rauter, P. Sinaÿ, Y. Blériot, Stereochemical assignment and first synthesis of the core of Miharamycin antibiotics, Chem. Eur. J., 2008, 14(32), 10066-10073 https://doi.org/10.1002/chem.200801826 (FI 5.317, NC: 9, top 4% setembro 2017, SCImago)