Por Federico Herrera (BioISI, Ciências ULisboa).

My research focuses on the molecular mechanisms underlying neurodegeneration and repair. We are especially interested in how pathological proteins self-organize and interact with other proteins, and how small covalent modifications such as phosphorylation or acetylation can influence the behavior of these proteins. We use a combination of genetic, biochemical and bioimaging approaches to study these phenomena in living cells. We have recently developed molecular tools and cellular models for the study of rare disorders as diverse as Huntington´s and Alexander´s diseases, Spastic Ataxia 8 (SPAX8), Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS), Inflammatory Hepatocellular Adenoma or Hyper-Immunoglobulin E syndrome.

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