- Delox – a spin-off that began to take shape at CIÊNCIAS. It develops biological decontamination tools and solutions
- R-nuucell – a start-up specialising in the development of chemotherapy treatments for aggressive cancers that spread through metastasis
- Keep it - a business specialising in the development of energy storage units that operate on the basis of hydropneumatic technology
- PETSys – one of the successful spin-offs founded on ideas that began at CIÊNCIAS, launched in 2008 with a solution that increases the resolution of diagnostic tests performed with PET technologies
- Vawlt – company specialising in the development of tools and solutions for storage, archiving and backup in cloud systems
- Science4You – brand specialising in the design and marketing of educational toys based on science and technology
- Nutrivalley – company that uses fungi to produce biodegradable materials from waste that serve as alternatives to plastics
- Phair Earth – company founded with the purpose of producing models that predict climate change decades in advance and with a level of detail that can reach up to a hundred metres